Stop taking isotretinoin and seek emergency medical attention or contact your doctor immediately if you experience any of the following serious side effects:

- an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
- changes in vision, blurred vision, or decreased vision (especially at night)
- painful or constant dryness of the eyes
- depression including feelings of sadness, crying spells, irritability, changes in sleep patterns, unusual tiredness, trouble concentrating, loss of appetite, and/ or suicidal thoughts or other mental problems
- stomach, chest, or bowel pain
- rectal bleeding, or severe or bloody diarrhea
- difficulty or pain when swallowing
- new or worsening heartburn
- yellowing of the skin or eyes or persistently dark urine
- severe headache or dizziness
- seizures
- nausea and vomiting
- joint or muscle pain or bone problems
- hearing problems or hearing loss
- trouble breathing
- fainting
- increased thirst or urination
- slurred speech or problems moving
- leg swelling
- increased levels of cholesterol or triglyceride (types of fat) in your blood (detected by blood tests)

Other, less serious side effects are more likely to occur. Continue to take isotretinoin and talk to your doctor if you experience:

- inflammation, dryness, or cracking of the lips
- dry skin, dry mouth, dry or bleeding nose, dryness of the eyes and/ or difficulty wearing contact lenses
- itching
- increased sensitivity of the skin to the sun

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

 

FDA Information

Why is this medication prescribed?

Other uses for this medicine

Dosage and using this medicine

What special precautions should I follow?

What should I do if I forget a dose?

What storage conditions are needed for this medicine?

In case of an emergency/overdose